Synthesis of propenamides with anti-malarial activities and 3D-QSAR study was written by Cheng, Maosheng;Yan, Dong;Wang, Qianli;Zhang, Li;Shen, Jianmin. And the article was included in Yaoxue Xuebao in 2003.Related Products of 28020-37-3 This article mentions the following:
The 3D-QSAR model of propenamides with anti-malarial activities was presented. The chem. synthesis combined with comparative mol. field anal. (CoMFA) was used. The QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6) were constructed. The activity of anti-W2 was depended mostly on steric interaction and the activity of anti-D6 was depended on both steric and electrostatic interaction. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Related Products of 28020-37-3).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 28020-37-3