Chitti, Surendar; Pulya, Sravani; Nandikolla, Adinarayana; Patel, Tarun Kumar; Karan Kumar, Banoth; Murugesan, Sankaranarayanan; Ghosh, Balaram; Sekhar, Kondapalli Venkata Gowri Chandra published the artcile< Design, synthesis and biological evaluation of 7-(5-((substituted - amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4'-piperidin]-4-one hydrochloride analogues as anticancer agents>, Recommanded Product: 3-(Aminomethyl)-6-(trifluoromethyl)pyridine, the main research area is spiro chromanpiperidinone hydrochloride preparation antitumor SAR ADME; Anticancer; Apoptosis; Cytotoxicity; Spiro-[chroman–2,4′–piperidin]–4–one.
A series of thirty-one novel 7-(5-((amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4′-piperidin]-4-one analogs I (R = isopropylamine, tert-butylamine, 3,3-dimethylbutylamine, etc.) have been designed and synthesized as their hydrochloride salts. Here, the anticancer potential and biol. results of low-mol.-weight bridgehead oxygen and nitrogen-containing spirochromanones on proliferation and apoptosis of the human breast cancer cell line (MCF-7) and murine melanoma (B16F10) is evaluated . The anticancer activity ranged from 2.9 to 35.0μM. The most potent compounds I (R = thiophen-2-yl methanamine, benzyl amine, and Me amine) were found to be less toxic against human embryonic kidney (HEK-293) cell lines. Compounds I (R = benzyl amine and Me amine) were found to be causing significant cytotoxicity through apoptotic cell death and also G2 phase arrest of cell cycle in B16F10 cells. In-silico ADME prediction studies of the titled compounds were found within the rules outlined, and these compounds may not face any pharmacokinetic associated issues in the mere future upon developmental stage. These conjugates may serve as a lead for the discovery of potential anticancer drug candidate with better therapeutic profile.
Bioorganic Chemistry published new progress about Antitumor agents. 387350-39-2 belongs to class pyridine-derivatives, and the molecular formula is C7H7F3N2, Recommanded Product: 3-(Aminomethyl)-6-(trifluoromethyl)pyridine.