Chitti, Surendar; Pulya, Sravani; Nandikolla, Adinarayana; Patel, Tarun Kumar; Banoth, Karan Kumar; Murugesan, Sankaranarayanan; Ghosh, Balaram; Chandra Sekhar Kondapalli, Venkata Gowri published the artcile< Design, synthesis and structure-activity relationship studies of novel spirochromanone hydrochloride analogs as anticancer agents>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is aminomethylphenyl spirochromanepiperidineone preparation anticancer mol docking SAR cytotoxicity; anticancer; apoptosis; cytotoxicity; molecular docking; spiro-[chromane-2,4′-piperidine]-4-one.
The authors designed and synthesized 18 spirochromanone derivs I [R = isopropylamino, cyclopentylamino, 4-methoxycyclohexylamino etc.]. The compounds I were characterized and evaluated for anticancer activity against human breast cancer (MCF-7) and murine melanoma (B16F10) cell lines. The anticancer activity ranged from 4.34 to 29.31 μm. The most potent compounds, I [R = dimethylamino, benzylamino] were less toxic against the human embryonic kidney (HEK-293) cell line and ∼ two/∼fourfold selective toward MCF-7 than B16F10 in comparison to the reference, BG-45. Compound , I [R = benzylamino] caused 28.6% total apoptosis, leading to significant cytotoxicity, and arrested the G2 phase of the cell cycle in B16F10 cells. A mol. docking study of compound , I [R = benzylamino] exhibited effective binding at the active site of the epidermal growth factor receptor kinase domain. This study highlights the importance of spirochromanones as anticancer agents.
Future Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.