Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model was written by Chowdhury, Sultan;Liu, Shifeng;Cadieux, Jay A.;Hsieh, Tom;Chafeev, Mikhail;Sun, Shaoyi;Jia, Qi;Sun, Jianyu;Wood, Mark;Langille, Jonathan;Sviridov, Serguei;Fu, Jianmin;Zhang, Zaihui;Chui, Ray;Wang, Audrey;Cheng, Xing;Zhong, Jing;Hossain, Sazzad;Khakh, Kuldip;Rajlic, Ivana;Verschoof, Henry;Kwan, Rainbow;Young, Wendy. And the article was included in Medicinal Chemistry Research in 2013.Recommanded Product: 5-Hydroxy-2-methoxylpyridine This article mentions the following:
The structure-activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNaV1.7 blocker with improved ADME properties and in vivo efficacy in the CFA-induced inflammatory pain model. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Recommanded Product: 5-Hydroxy-2-methoxylpyridine).
5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 5-Hydroxy-2-methoxylpyridine