Church, Robert; Trust, Ronald; Albright, J. Donald; Powell, Dennis published an article in Journal of Organic Chemistry. The title of the article was 《New Synthetic Routes to 3-, 5-, and 6-Aryl-2-chloropyridines》.Application of 10177-08-9 The author mentioned the following in the article:
The efficient synthesis of 3-, 5-, and 6-aryl-2-chloropyridines, e.g., I (R1 = H, 3-pyridinyl, SO2Ph, etc., R2 = H, 3-F3CC6H4, 2,4-Cl2C6H3, 4-Ph, etc., R3 = H, Ph, 3-pyridinyl, etc.), via the facile preparation of 5-(dimethyamino)aryl-substituted pentadienyl nitriles and cyclization with hydrochloric acid is described. This approach allows for the introduction of other electron-withdrawing substituents on the pyridine ring as well as the preparation of the desired unsubstituted arylpyridines. Some differences in the rates of cyclization of the pentadienyl nitriles as well as the yields of chloropyridines were observed that depended on the position and degree of substitution in the aryl substituent. The arylpentadienyl nitriles Me2NCH:CCHCH:CArCN (Ar = 3-pyridinyl, 3-F3CC6H4, 3-MeOC6H4, Ph) could also be converted directly into the corresponding 2-aminopyridines. In the experiment, the researchers used 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Application of 10177-08-9)
2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 10177-08-9 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.