Cieplik, Fabian; Kara, Esra; Muehler, Denise; Enax, Joachim; Hiller, Karl-Anton; Maisch, Tim; Buchalla, Wolfgang published the artcile< Antimicrobial efficacy of alternative compounds for use in oral care toward biofilms from caries-associated bacteria in vitro>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is chlorhexidine digluconate streptococcus actinomyces biofilms propidium iodide polymicrobial; antimicrobial; biofilm; cetylpyridinium chloride; chlorhexidine; citrus extract; dental caries.
For caries-active patients, antimicrobial measures may be useful in addition to mech. biofilm removal. The aim of this study was to investigate the antimicrobial efficacy of alternative compounds for use in oral care from two main categories (i.e., preservatives and natural compounds) toward biofilms from caries-associated bacteria as compared to oral care gold-standards chlorhexidine digluconate (CHX), Streptococcus mutans (CPC), and zinc. Compounds were screened in initial Streptococcus mutans biofilms. Then, the most effective compounds were further investigated in mature S. mutans and polymicrobial biofilms comprising Actinomyces naeslundii,Actinomyces odontolyticus, and S. mutans. Biofilms were visualized by SEM and bacterial membrane damage was evaluated by means of flow cytometry and staining with SYBR Green and propidium iodide. Citrus extract was the only compound exhibiting similar antimicrobial efficacy in initial S. mutans biofilms (>5 log10) as compared to CHX and CPC, but its effect was clearly inferior in mature S. mutans and polymicrobial biofilms. From all alternative compounds investigated in this study, citrus extract exhibited the highest antimicrobial efficacy toward in vitro biofilms from caries-associated bacteria, but still was less effective than oral care gold-standard antiseptics CHX and CPC. Nevertheless, citrus extract may be a valuable antimicrobial compound for use in oral care for caries-active patients.
MicrobiologyOpen published new progress about Actinomyces naeslundii. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.