Indolizine derivatives with biological activity. VI. 1-(2-Aminoethyl)-3-benzyl-7-methoxy-2-methylindolizine, benanserine structural analog was written by Cingolani, G. M.;Claudi, F.;Massi, M.;Venturi, F.. And the article was included in European Journal of Medicinal Chemistry in 1990.Computed Properties of C7H9NO This article mentions the following:
The title compound (I) was prepared from 3-(4-methoxy-2-pyridyl)propionate. In comparison with benanserine I showed greatly reduced antihistaminic activity and somewhat reduced antiserotonin activity whereas the anticholinergic activity remained unaffected. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Computed Properties of C7H9NO).
4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C7H9NO