Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study was written by Clasen, Joanna L.;Heath, Alicia K.;Van Puyvelde, Heleen;Huybrechts, Inge;Park, Jin Young;Ferrari, Pietro;Scelo, Ghislaine;Ulvik, Arve;Midttun, oeivind;Ueland, Per Magne;Overvad, Kim;Eriksen, Anne Kirstine;Tjoenneland, Anne;Kaaks, Rudolf;Katzke, Verena;Schulze, Matthias B.;Palli, Domenico;Agnoli, Claudia;Chiodini, Paolo;Tumino, Rosario;Sacerdote, Carlotta;Zamora-Ros, Raul;Rodriguez-Barranco, Miguel;Santiuste, Carmen;Ardanaz, Eva;Amiano, Pilar;Schmidt, Julie A.;Weiderpass, Elisabete;Gunter, Marc;Riboli, Elio;Cross, Amanda J.;Johansson, Mattias;Muller, David C.. And the article was included in International Journal of Cancer in 2022.Related Products of 54-47-7 The following contents are mentioned in the article:
Previous studies have suggested that components of one-carbon metabolism, particularly circulating vitamin B6, have an etiol. role in renal cell carcinoma (RCC). Vitamin B6 is a cofactor in the transsulfuration pathway. We sought to holistically investigate the role of the transsulfuration pathway in RCC risk. We conducted a nested case-control study (455 RCC cases and 455 matched controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Plasma samples from the baseline visit were analyzed for metabolites of the transsulfuration pathway, including pyridoxal 5′-phosphate (PLP, the biol. active form of vitamin B6), homocysteine, serine, cystathionine, and cysteine, in addition to folate. Bayesian conditional logistic regression was used to estimate associations of metabolites with RCC risk as well as interactions with established RCC risk factors. Circulating PLP and cysteine were inversely associated with RCC risk, and these associations were not attenuated after adjustment for other transsulfuration metabolites (odds ratio (OR) and 90% credible interval (CrI) per 1 SD increase in log concentration: 0.76 [0.66, 0.87]; 0.81 [0.66, 0.96], resp.). A comparison of joint metabolite profiles suggested substantially greater RCC risk for the profile representative of low overall transsulfuration function compared to high function (OR 2.70 [90% CrI 1.26, 5.70]). We found some statistical evidence of interactions of cysteine with body mass index, and PLP and homocysteine with smoking status, on their associations with RCC risk. In conclusion, we found evidence suggesting that the transsulfuration pathway may play a role in metabolic dysregulation leading to RCC development. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Related Products of 54-47-7).
(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 54-47-7