Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols was written by Colgan, Avene C.;Proctor, Rupert S. J.;Gibson, David C.;Chuentragool, Padon;Lahdenpera, Antti S. K.;Ermanis, Kristaps;Phipps, Robert J.. And the article was included in Angewandte Chemie, International Edition in 2022.Related Products of 644-98-4 This article mentions the following:
Catalytic enantioselective Minisci reactions have recently been developed but all instances so far utilize α-amino radical coupling partners. Authors report a substantial evolution of the enantioselective Minisci reaction that enables α-hydroxy radicals to be used, providing valuable enantioenriched secondary alc. products. This is achieved through the direct oxidative coupling of two C-H bonds on simple alc. and pyridine partners through a hydrogen atom transfer (HAT)-driven approach: a challenging process to achieve due to the numerous side reactions that can occur. This approach is highly regioselective as well as highly enantioselective. Dicumyl peroxide, upon irradiation with 390 nm light, serves as both HAT reagent and oxidant while selectivity is controlled by use of a chiral phosphoric acid catalyst. Computational and exptl. evidence provide mechanistic insight as to the origin of selectivity, revealing a stereodetermining deprotonation step distinct from the analogous reaction of amide-containing substrates. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Related Products of 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 644-98-4