Cory, Joseph G. published the artcileSubstituted 2-acylpyridine-α-(N)-hetarylhydrazones as inhibitors of ribonucleotide reductase activity and L1210 cell growth, Quality Control of 2215-33-0, the publication is Anticancer Research (1994), 14(3A), 875-9, database is CAplus and MEDLINE.
A series of substituted 2-acylpyridine-α-(N)-hetarylhydrazones was prepared and studied for their effects on mammalian ribonucleotide reductase activity using a highly purified enzyme preparation from Ehrlich tumor cells and on mouse leukemia L1210 cell growth in culture. Pyridine-2-aldehyde-2-pyridylhydrazone (PH 22), ethyl-2-pyridylketone-1-phthalazinylhydrazone (PH 22-25) and pyridine-2-aldehyde-2′-quinolylhydrazone (PQ 22) inhibited purified ribonucleotide reductase activity and inhibited L1210 cell growth in culture. PH 22-25 inhibited [3H]thymidine incorporation into DNA and inhibited ribonucleotide reductase activity in situ (as measured by [14C]cytidine metabolism) and as a result inhibited DNA synthesis. There was no effect on RNA synthesis. These data indicate that these substituted hydrazones are potent inhibitors of tumor cell growth through the inhibition of ribonucleotide reductase.
Anticancer Research published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Quality Control of 2215-33-0.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem