Beak, Peter; Covington, Johnny B.; Smith, Stanley G.; White, J. Matthew; Zeigler, John M. published the artcile< Displacement of protomeric equilibriums by self-association: hydroxypyridine-pyridone and mercaptopyridine-thiopyridone isomer pairs>, COA of Formula: C5H4ClNO, the main research area is tautomerism pyridinol pyridinethiol association; solvent effect association pyridinol.
Self-association and protomeric equilibrium constants are reported for 2-hydroxypyridine-2-pyridone, 4-hydroxypyridine-4-pyridone and 2-mercaptopyridine-2-thiopyridone isomer pairs in different solvents. These results provide quant. evidence for significant differences in the positions of protomeric equilibrium for self-associated and monomeric species. The 2-substituted isomers are associated as well-known dimers while the 4-substituted systems form oligomers. In polar and H-bonding solvents self-association is substantially reduced. Sterically hindered 2- and 4-pyridones are less associated than unhindered systems. These results imply that determinations and interpretations of protomeric equilibrium should take into account the possible dominance of self-association
Journal of Organic Chemistry published new progress about Self-association. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, COA of Formula: C5H4ClNO.