On January 31, 2004, Crider, A. M.; Liu, S.; Li, T.; Mahajan, S.; Ankersen, M.; Stidsen, C. E. published an article.Category: pyridine-derivatives The title of the article was Somatostatin receptor subtype 4 (sst4) ligands: Synthesis and evaluation of indol-3-yl- and 2-pyridyl-thioureas. And the article contained the following:
Thiourea analogs of NNC 26-9100 (2) were prepared as somatostatin receptor subtype 4 (sst4) ligands. The indole 9 exhibited high affinity (Ki = 23 nM) and about a 100-fold selectivity at sst4 compared to sst2 receptors. The (imidazol-4-yl) Pr group appears to play a major role in the affinity and selectivity of these thioureas at sst4. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Category: pyridine-derivatives
The Article related to somatostatin receptor sst4 thiourea ligand, Pharmacology: Structure-Activity and other aspects.Category: pyridine-derivatives