In 2016,Cross, Jason B.; Zhang, Jing; Yang, Qingyi; Mesleh, Michael F.; Romero, Jan Antoinette C.; Wang, Bin; Bevan, Doug; Poutsiaka, Katherine M.; Epie, Felix; Moy, Terence; Daniel, Anu; Shotwell, Joseph; Chamberlain, Brian; Carter, Nicole; Andersen, Ole; Barker, John; Ryan, M. Dominic; Metcalf, Chester A. III; Silverman, Jared; Nguyen, Kien; Lippa, Blaise; Dolle, Roland E. published 《Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design》.ACS Medicinal Chemistry Letters published the findings.SDS of cas: 29682-15-3 The information in the text is summarized as follows:
The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment screening hit scaffold using structure guided design. These inhibitors show potent Gram-pos. antibacterial activity and low resistance incidence against clin. important pathogens. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3SDS of cas: 29682-15-3)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 29682-15-3