The author of 《Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides》 were Cui, Xin-Feng; Ban, Zi-Hui; Tian, Wa-Fa; Hu, Fang-Peng; Zhou, Xiao-Qiang; Ma, Hao-Jie; Zhan, Zhen-Zhen; Huang, Guo-Sheng. And the article was published in Organic & Biomolecular Chemistry in 2019. Category: pyridine-derivatives The author mentioned the following in the article:
Indole is a ubiquitous structural motif with important applications in many areas of chem. Given this, a simple and efficient Ru(II)-catalyzed synthesis of indoles I (R = Ph, 4-FC6H4, 3-ClC6H4, 2-thienyl, cyclohexyl, etc., R1 = H, 5-Me, 5-MeO, 6-F, 5-Me-6-Cl, etc., R2 = H, 5-Me, 4-Me, 5-Cl, 5-Br) via intermol. annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed This protocol provides easy access to a wide variety of useful indoles in the presence of a com. available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Category: pyridine-derivatives)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives