Decarboxylative Arylation of Pyridine 1-Oxides and Anilides with Benzoic Acid via Palladium-Catalyzed C-H Functionalization was written by Dabiri, Minoo;Alavioon, Seyed Iman;Movahed, Siyavash Kazemi. And the article was included in European Journal of Organic Chemistry in 2019.Product Details of 3718-65-8 This article mentions the following:
A novel method for the palladium-catalyzed decarboxylative ortho C-H bond arylation of pyridine 1-oxides I [R1 = H, 3-Cl, 3-C(O)OCH2CH3, 4-CN, etc.] and anilides R2NHC(O)R3 [R2 = C6H5, 4-BrC6H4, 3,4-(H3CO)2C6H3, etc.; R3 = C(CH3)3, C6H5] with benzoic acids R4C6H4C(O)OH [R4 = 4-CF3, 4-F, 4-NO2, 2-Br, 3-CH3, etc.] as aryl sources is described. The established methodol. provides a direct approach for the synthesis of 2-arylpyridine 1-oxides II and 2-aryl anilides 4-R5-5-R6-2-(R4C6H4)C6H2NHC(O)R3 (R5 = H, Br, Me, CF3, F, Cl, MeO; R6 = H, Cl, Me, MeO) in good isolated yields. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Product Details of 3718-65-8).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 3718-65-8