Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines was written by Dai, Liyan;Fang, Jun;Wang, Xiaozhong;Chen, Yingqi. And the article was included in Huagong Xuebao (Chinese Edition) in 2007.Computed Properties of C7H6N2 This article mentions the following:
The preparation of a series of 2-pyridinamines and their alkyl derivatives is described. The target compounds are synthesized starting from corresponding 2-cyanopyridines, via incomplete hydrolysis in the presence of hydrogen peroxide in the dilute alk. mixture of acetone-2% sodium hydroxide solution, and Hoffmann degradation reaction with freshly made NaBrO. This route is of industrial value because of cheap and readily available materials, moderate reaction conditions and convenient operations. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Computed Properties of C7H6N2).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C7H6N2