In 2008,Synthetic Communications included an article by Dai, Liyan; Fan, Dongbo; Wang, Xiaozhong; Chen, Yingqi. Product Details of 153476-68-7. The article was titled 《Improved synthetic approach to tenatoprazole》. The information in the text is summarized as follows:
An improved synthetic approach to tenatoprazole I was described. It started from 2,3,5-trimethyl-4-nitropyridine-N-oxide with acetic anhydride via rearrangement and hydrolysis to give 2-hydroxymethyl-3,5-dimethyl-4-nitropyridine, chlorination with SOCl2 yielded 2-chloromethyl-3,5-dimethyl-4-nitropyridine hydrochloride (II), then II condensed with 2-mercapto-5-methoxyimidazole[4,5-b]pyridine to give 5-methoxy-2-[(4-nitro-3,5-dimethyl-2-pyridinyl)methylthio]imidazole[4,5-b]pyridine (III). At last the title compound I was produced by two methods: the compound III was oxidized with MCPBA and then methoxylated with CH3ONa to give I and III was first methoxylated with CH3ONa and then oxidized with MCPBA to give I. The overall yield was around 26% for both five-step syntheses. In the part of experimental materials, we found many familiar compounds, such as 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7Product Details of 153476-68-7)
2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 153476-68-7