Das, Athulya; Rajeev, Anjana; Bhunia, Sarmistha; Arunkumar, Manivel; Chari, Nithya; Sankaralingam, Muniyandi published an article in 2021. The article was titled 《Synthesis, characterization and antimicrobial activity of nickel(II) complexes of tridentate N3 ligands》, and you may find the article in Inorganica Chimica Acta.SDS of cas: 1539-42-0 The information in the text is summarized as follows:
The desire to develop new antimicrobial agents against the rising threat of extensive antibiotic resistance led to the exploration of many natural and synthetic compounds Herein, the authors report the isolation and structural characterization of Ni(II) complexes [Ni(L)2]2+ (1 and 2) of tridentate N3 ligands such as bis(pyridin-2-ylmethyl)amine (L1) and 1-(1-methyl-1H-imidazol-2-yl)-N-(pyridin-2-ylmethyl)methanamine (L2). Both the complex cations of [Ni(L1)2]2+ (1) and [Ni(L2)2]2+ (2) possess a distorted octahedral coordination geometry in which Ni(II) is chelated to two equivalent of the tridentate L1 and L2 ligand in facial coordination, resp. 1 And 2 exhibit the bands in the visible region in UV-visible spectra and peaks in the downfield region in paramagnetic NMR spectra suggesting the octahedral coordination geometry of the complexes in solution as well. Further, complexes 1 and 2 were evaluated for their antimicrobial activity against various clin. pathogens. With in vitro studies, 1 displayed activity against Vibrio parahaemolyticus and V. alginolyticus, Staphylococcus aureus, Candida albicans, and Salmonella typhi, and 2 displayed activity against S. aureus, S. typhi, and C. albicans. With in vivo studies, complex 1 was effective in inhibiting Vibrio infection in brine shrimp larvae while having no toxicity on the larvae. The authors believe these results will encourage medicinal chemists to further the study on metal complexes against multi-resistant pathogens.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0) was used in this study.
Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. SDS of cas: 1539-42-0