Pd2dba3/P(t-Bu)3H.BF4/Cy2NMe Catalyzed Heck Coupling in Synthesis of 3-Alkenyl-1H-Isochromen-1-Ones was written by Dasaradhan, Changalaraya;Nawaz Khan, Fazlur-Rahman. And the article was included in Polycyclic Aromatic Compounds in 2022.Application of 85838-94-4 This article mentions the following:
An efficient catalytic system comprising Pd2dba3/P(t-Bu)3H.BF4/Cy2NMe -for the Heck coupling in the synthesis of 3-alkenyl isochromen-1-ones, I (R = H, 6,7-(OMe)2; R1 = Ph, benzyl, pyridin-2-yl), II (R2 = OH, OMe, NH2, butoxy) and III (R3 = 3,6-dihydro-2H-pyran-4-yl, 1-[(tert-butoxy)(oxo)methane]-1,2,5,6-tetrahydropyridin-3-yl) has been developed. Air stable alkyl phosphonium salt, [(t-Bu)3Ph]BF4 was found to be vital for the activation of 3- chloroisochromen-1-one and 3-chloro-6,7-dimethoxy-1H-isochromen-1-one, in regio-selective Heck coupling reactions. The technique has addnl. been reached out to typharin I, penicilisorin II and artemidin analogs III. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Application of 85838-94-4).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 85838-94-4