Highly Regio-, Diastereo-, and Enantioselective C-H Insertions of Methyl Aryldiazoacetates into Cyclic N-Boc-Protected Amines. Asymmetric Synthesis of Novel C2-Symmetric Amines and threo-Methylphenidate was written by Davies, Huw M. L.;Hansen, Tore;Hopper, Darrin W.;Panaro, Stephen A.. And the article was included in Journal of the American Chemical Society in 1999.Product Details of 85838-94-4 This article mentions the following:
The reaction of cyclic N-Boc-protected amines (e.g., N-Boc-pyrrolidine, -piperidine, and -1,2,3,6-tetrahydropyridine) with aryldiazoacetates R1C(:N2)CO2Me (R1 = Ph, p-ClC6H4, p-MeC6H4, 2-naphthyl, p-MeOC6H4) catalyzed by Rh2(S-DOSP)4 or Rh2(S-biDOSP)2 [DOSP = N-[(4-dodecylphenyl)sulfonyl]prolinate] is proposed as a method for the asym. synthesis of chiral amines I and II and threo-methylphenidate (Ritalin). Thus C-H insertions with the above aryldiazoacetates can be achieved with high regio-, diastereo-, and enantioselectivity. These carbenoids are particularly selective toward C-H insertions into methylene groups adjacent to an amide nitrogen. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Product Details of 85838-94-4).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 85838-94-4