de Assis, Ellen Lima; Silveira, Felipe Dantas; da Ponte, Alan Victor Araujo; Regis, Romulo Rocha published the artcile< A Systematic Review of the Potential Effects of Lippia sidoides on Dental Plaque and Periodontal Diseases>, Formula: C21H38ClN, the main research area is Lippia sidoides dental plaque periodontal disease potential effect.
Lippia sidoidesis a typical shrub from Brazil that has been used in traditional medicine. This is a systematic review on the effect of L. sidoidesfor controlling dental plaque, gingivitis, and periodontitis. A database search through May 2021 in Medline/PubMed, SCOPUS, BVS, and Web of Science identified 711 reports of which 17 met our inclusion criteria. Five randomized controlled trials and three animal studies were included that compared L. sidoides-based products (toothpaste, mouthrinse, and gel) to cetylpyridinium chloride, chlorhexidine, and placebo products. Among the human studies, a significant antiplaque effect after treatment with L. sidoides-based products was observed in three studies and an antigingivitis effect in two studies, similar to chlorhexidine-based products. One study found superior dental plaque reduction compared to cetylpyridinium chloride mouthrinse. Only one study testing a L. sidoidesgel found no antiplaque effect. Among the animal studies, an L. sidoidesmouthrinse significantly reduced calculus in two studies, inflammatory infiltrate in one study, and plaque bacteria and gingivitis in one study. An L. sidoidesgel significantly reduced alveolar bone loss and inflammatory response in one study in which mice were submitted to ligature-induced periodontal disease. In general, L. sidoides-based products were effective in reducing dental plaque and calculus formation, as well as clin. signs of gingivitis. As most studies present methodol. limitations, these results should be interpreted carefully. Further clin. trials with greater methodol. accuracy and control of biases are necessary for the use of L. sidoides-based products in humans to be viable in clin. practice.
Planta Medica published new progress about Alveolar bone. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.