de la Fuente-Herreruela, Diego; Monnappa, Ajay K.; Munoz-Ubeda, Monica; Morallon-Pina, Aaron; Enciso, Eduardo; Sanchez, Luis; Giusti, Fabrice; Natale, Paolo; Lopez-Montero, Ivan published the artcile< Lipid-peptide bioconjugation through pyridyl disulfide reaction chemistry and its application in cell targeting and drug delivery>, Product Details of C10H8N2S2, the main research area is lipid peptide bioconjugation pyridyl disulfide liposome delivery cell target; Disulfide bonds; Endosomal escape; GALA; Smart liposomes; Targeting peptide.
The design of efficient drug delivery vectors requires versatile formulations able to simultaneously direct a multitude of mol. targets and to bypass the endosomal recycling pathway of cells. Liposomal-based vectors need the decoration of the lipid surface with specific peptides to fulfill the functional requirements. The unspecific binding of peptides to the lipid surface is often accompanied with uncontrolled formulations and thus preventing the mol. mechanisms of a successful therapy. We present a simple synthesis pathway to anchor cysteine-terminal peptides to thiol-reactive lipids for adequate and quant. liposomal formulations. As a proof of concept, we have synthesized two different lipopeptides based on (a) the truncated Fibroblast Growth Factor (tbFGF) for cell targeting and (b) the pH sensitive and fusogenic GALA peptide for endosomal scape. The incorporation of these two lipopeptides in the liposomal formulation improves the fibroblast cell targeting and promotes the direct delivery of cargo mols. to the cytoplasm of the cell.
Journal of Nanobiotechnology published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.