On May 31, 1999, Decristoforo, Clemens; Mather, Stephen J. published an article.Product Details of 636-73-7 The title of the article was 99M-technetium-labelled peptide-HYNIC conjugates: Effects of lipophilicity and stability on biodistribution. And the article contained the following:
The aim of this study was to explore the effects of lipophilicity and stability on the biodistribution of 99mTc labeled peptides through the use of different co-ligands. 6-Hydrazinopyridine-3-carboxylic acid (HYNIC) was coupled to the somatostatin analog RC160 and radiolabeled using a range of ethylenediaminediacetic acid (EDDA) and EDTA derivatives as well as tricine and pyridine/tricine as co-ligands. After labeling with technetium-99m, chromatog., stability, protein-binding, and rat biodistribution studies were performed. For most co-ligands, biodistribution correlated well with in vitro properties. Lipophilic substitution on EDDA resulted in higher protein binding, increased liver uptake, and intestinal excretion. Stabilization of tricine with pyridines reduced blood levels and lowered liver uptake. EDTA derivatives showed high instability in vitro and in vivo. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Product Details of 636-73-7
The Article related to technetium 99m somatostatin analog complex biodistribution, rc160 hynic technetium 99m complex biodistribution, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Product Details of 636-73-7