In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of a TRPV1 Receptor Antagonist, published in 2009-12-18, which mentions a compound: 894086-00-1, mainly applied to chloromethylindazole dimethylbutyl trifluoromethylphenylmethyl urea palladium Bippyphos coupling; dimethylbutyl trifluoromethylphenylmethyl methylindazolyl urea preparation TRPV1 receptor antagonist; coupling catalyst palladium Bippyphos, Name: 5-(di-tert-Butylphosphino)-1′,3′,5′-triphenyl-1’H-1,4′-bipyrazole.
A five-step synthesis of TRPV1 receptor antagonist I is described. The key step involves a novel palladium-catalyzed coupling reaction of 4-chloro-1-methylindazole with the benzyl urea to form the unsym. substituted urea I.
In addition to the literature in the link below, there is a lot of literature about this compound(5-(di-tert-Butylphosphino)-1′,3′,5′-triphenyl-1’H-1,4′-bipyrazole)Name: 5-(di-tert-Butylphosphino)-1′,3′,5′-triphenyl-1’H-1,4′-bipyrazole, illustrating the importance and wide applicability of this compound(894086-00-1).