Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reference of 766-11-0.
Deng, Xiaoyun;Zhang, Yiding;Rong, Jian;Kumata, Katsushi;Shao, Tuo;Wang, Gangqiang;Hatori, Akiko;Mori, Wakana;Yu, Qingzhen;Hu, Kuan;Fujinaga, Masayuki;Shao, Yihan;Josephson, Lee;Sun, Shaofa;Zhang, Ming-Rong;Liang, Steven research published 《 Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4》, the research content is summarized as follows. The synthesis and preliminary evaluation of a 18F-labeled positron emission tomog. ligand based on a M4 activator I. 18F-Isotopologue was prepared I in a reasonable radiochem. yield with high radiochem. purity (>99%) and high molar activity (>37 GBq/μmol). In-vitro autoradiog. studies indicated that the ligand possessed moderate in-vitro specific binding. Dynamic PET studies in-vivo demonstrated that [18F]I (also named as [18F]M4R-1911) failed to cross the blood-brain barrier. Therefore, further chem. scaffold optimization in chemotype of I was necessary to overcome limited brain permeability and improve specific binding.
Reference of 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.