《Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent》 was written by Deng, Zhijie; Zhao, Mingxin; Wang, Feng; Tang, Pingping. Reference of 4-CyanopyridineThis research focused ontrifluoromethoxylated compound preparation regioselective; arene heteroarene trifluoromethyl arylsulfonate trifluoromethoxylation. The article conveys some information:
A general late-stage C-H trifluoromethoxylation of arenes and heteroarenes RH (R = 4-methoxypyridin-2-yl, 4-t-butylphenyl, 3-acetylbenzothien-2-yl, etc.) as limiting reagent with trifluoromethoxide anion was described. The reaction is mediated by silver salts under mild reaction conditions, exhibiting broad substrate scope and wide functional-group compatibility. In addition, ortho-position selective C-H trifluoromethoxylation of pyridines is observed The method is not only applicable to the gram-scale synthesis of trifluoromethoxylated products ROCF3 but also allows efficient late-stage C-H trifluoromethoxylation of marketed small-mol. drugs, common pharmacophores and natural products. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of 4-Cyanopyridine