In 2022,Denisov, Gleb L.; Nelyubina, Yulia V. published an article in Crystals. The title of the article was 《New Co-Crystals/Salts of Gallic Acid and Substituted Pyridines: An Effect of Ortho-Substituents on the Formation of an Acid-Pyridine Heterosynthon》.Recommanded Product: 141-86-6 The author mentioned the following in the article:
Co-crystallization of gallic acid with pyridines and their polyaromatic analog, quinoline, ortho-substituted by various proton-donating groups able to form hydrogen bonds, produced the only reported co-crystal of gallic acid with an ortho-substituted pyridine, 2-hydroxypyridine, as its preferred pyridone-2 tautomer, and four new crystalline products of gallic acid. These co-crystals, or gallate salts depending on the choice of the pyridine-containing compound, as predicted by the pKa rule, were identified by X-ray diffraction to feature the popular acid-pyridine heterosynthon found in most of the two-component systems of gallic acid that lack ortho-substituents in the pyridine-containing compound This single-point heterosynthon is, however, modified by one or two proton-donating ortho-substituents, which sometimes may transform into the proton acceptors in an adopted tautomer or zwitterion, to produce its two- or other multi-point variants, including a very rare four-point heterosynthon. The hydrogen bonds they form with the gallic acid species in the appropriate co-crystals/salts strongly favors the formation of the acid-pyridine heterosynthon over the acid-acid homosynthon. In the competitive conditions of multi-component systems, such a modification might be used to reduce supramol.-synthon-based polymorphism to produce new pharmaceuticals and other crystalline materials with designed properties. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6)
2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6