Recommanded Product: 128071-75-0In 2018 ,《Nickel-Catalyzed Tandem Knoevenagel Condensation and Intramolecular Direct Arylation: Synthesis of Pyrazolo[5,1-a]-isoquinoline Derivatives》 appeared in Advanced Synthesis & Catalysis. The author of the article were Dhiman, Shiv; Nandwana, Nitesh Kumar; Saini, Hitesh Kumar; Kumar, Dalip; Rangan, Krishnan; Robertson, Katherine N.; Jha, Mukund; Kumar, Anil. The article conveys some information:
A simple and efficient method for the synthesis of pyrazolo[5,1-a]isoquinoline derivatives has been developed using the nickel-catalyzed reaction of 1-aryl-2-(1H-pyrazol-1-yl)ethan-1-ones and 2-bromo aldehydes [e.g., I + 2-bromobenzaldehyde → II (68%) in presence of Ni(acac)2, PCy3 and K2CO3 in DMSO]. The overall transformation involves tandem Knoevenagel condensation and intramol. direct arylation via activation of the C5-H bond of the pyrazole ring. A series of 27 drug-like aroyl-substituted pyrazolo[5,1-a]isoquinolines has been synthesized in moderate to good yields. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 128071-75-0