Dihydropyrrole[2,3-d]pyridine Derivatives as Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping of the Receptor Binding Pocket by in Silico Docking Studies was written by Di Fabio, Romano;Arban, Roberto;Bernasconi, Giovanni;Braggio, Simone;Blaney, Frank E.;Capelli, Anna M.;Castiglioni, Emiliano;Donati, Daniele;Fazzolari, Elettra;Ratti, Emiliangelo;Feriani, Aldo;Contini, Stefania;Gentile, Gabriella;Ghirlanda, Damiano;Sabbatini, Fabio M.;Andreotti, Daniele;Spada, Simone;Marchioro, Carla;Worby, Angela;St-Denis, Yves. And the article was included in Journal of Medicinal Chemistry in 2008.Application In Synthesis of 3-Amino-2,6-dimethoxypyridine This article mentions the following:
In an effort to discover novel CRF-1 receptor antagonists exhibiting improved physicochem. properties, a dihydropirrole[2,3]pyridine scaffold was designed and explored in terms of the SAR of the substitution at the pendent Ph ring and the nature of the heterocyclic moieties present in the upper region of the mol. Selective and potent compounds have been discovered endowed with reduced ClogP with respect to compounds known in the literature. Of particular relevance was the finding that the in vitro affinity of the series was maintained by reducing the overall lipophilicity. The results achieved by this exploration enabled the formulation of a novel hypothesis on the nature of the receptor binding pocket of this class of CRF-1 receptor antagonists, making use of in silico docking studies of the putative nonpeptidic antagonist binding site set up in house by homol. modeling techniques. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Application In Synthesis of 3-Amino-2,6-dimethoxypyridine).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 3-Amino-2,6-dimethoxypyridine