《Asymmetric Synthesis of Multifunctionalized 2,3-Benzodiazepines by a One-pot N-Heterocyclic Carbene/Chiral Palladium Sequential Catalysis》 was published in Journal of Organic Chemistry in 2020. These research results belong to Ding, Ya-Li; Zhao, Yun-Long; Niu, Shuang-Shuo; Wu, Pei; Cheng, Ying. Computed Properties of C6H4BrNO The article mentions the following:
The first example of the construction of chiral 2,3-benzodiazepine compounds which are of biol. and pharmaceutical relevance by asym. catalysis is reported. Catalyzed by a thiazolium derived carbene and a palladium-chiral bidentate phosphine complex in sequence, one-pot reaction between 1-(2-(2-nitrovinyl)aryl)allyl esters with azodicarboxylates took place efficiently at ambient temperature to produce 4-nitro-1-vinyl-1H-2,3-benzodiazepine-2,3-dicarboxylates I (R = Me, Et, iPr; Z = C, N; X, Y = H, Me, Cl, etc.) in good to excellent yields with an enantiomeric ratio up to 95 : 5. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Computed Properties of C6H4BrNO)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C6H4BrNO