Related Products of 31251-41-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 31251-41-9, Name is 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, SMILES is O=C1C2=CC=C(Cl)C=C2CCC3=CC=CN=C31, belongs to pyridine-derivatives compound. In a article, author is Li, Jia-Qi, introduce new discover of the category.
Diaryl-substituted thiosemicarbazone: A potent scaffold for the development of New Delhi metallo-beta-lactamase-1 inhibitors
The superbug infection caused by New Delhi metallo-beta-lactamase (NDM-1) has become an emerging public health threat. Inhibition of NDM-1 has proven challenging due to its shuttling between pathogenic bacteria. A potent scaffold, diaryl-substituted thiosemicarbazone, was constructed and assayed with metallo-beta-lactamases (M beta Ls). The obtained twenty-six molecules specifically inhibited NDM-1 with IC50 0.038-34.7 mu M range (except 1e, 2e, and 3d), and 1c is the most potent inhibitor (IC50 = 0.038 mu M). The structure-activity relationship of synthetic thiosemicarbazones revealed that the diaryl-substitutes, specifically 2-pyridine and 2-hydroxylbenzene improved inhibitory activities of the inhibitors. The thiosemicarbazones exhibited synergistic antimycobacterial actions against E. coli-NDM-1, resulted a 2-512-fold reduction in MIC of meropenem, while 1c restored 16-256-, 16-, and 2-fold activity of the antibiotic on clinical isolates ECs, K. pneumonia and P. aeruginosa harboring NDM-1, respectively. Also, mice experiments showed that 1c had a synergistic antibacterial ability with meropenem, reduced the bacterial load clinical isolate EC08 in the spleen and liver. This work provided a highly promising scaffold for the development of NDM-1 inhibitors.
Related Products of 31251-41-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 31251-41-9 is helpful to your research.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem