Discovery of 91-02-1

Welcome to talk about 91-02-1, If you have any questions, you can contact Murayama, H; Heike, Y; Higashida, K; Shimizu, Y; Yodsin, N; Wongnongwa, Y; Jungsuttiwong, S; Mori, S; Sawamura, M or send Email.. HPLC of Formula: C12H9NO

In 2020.0 ADV SYNTH CATAL published article about ASYMMETRIC TRANSFER HYDROGENATION; LIGAND BIFUNCTIONAL CATALYSIS; RUTHENIUM COMPLEX; AROMATIC KETONES; BASIS-SETS; METAL; REDUCTION; ALDEHYDES; DESIGN; ESTERS in [Murayama, Hiroaki; Heike, Yoshito; Higashida, Kosuke; Shimizu, Yohei; Sawamura, Masaya] Hokkaido Univ, Fac Sci, Dept Chem, Sapporo, Hokkaido 0600810, Japan; [Higashida, Kosuke; Shimizu, Yohei; Sawamura, Masaya] Hokkaido Univ, Inst Chem React Design & Discovery WPI ICReDD, Sapporo, Hokkaido 0010021, Japan; [Yodsin, Nuttapon; Wongnongwa, Yutthana; Jungsuttiwong, Siriporn] Ubon Ratchathani Univ, Fac Sci, Dept Chem, Ctr Organ Elect & Alternat Energy, Ubon Ratchathani 34190, Thailand; [Yodsin, Nuttapon; Wongnongwa, Yutthana; Jungsuttiwong, Siriporn] Ubon Ratchathani Univ, Fac Sci, Ctr Excellence Innovat Chem, Ubon Ratchathani 34190, Thailand; [Mori, Seiji] Ibaraki Univ, Inst Quantum Beam Sci, Mito, Ibaraki 3108512, Japan in 2020.0, Cited 53.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. HPLC of Formula: C12H9NO

Iridium-catalyzed enantioselective transfer hydrogenation of ketones with formic acid was developed using a prolinol-phosphine chiral ligand. Cooperative action of the iridium atom and the ligand through alcohol-alkoxide interconversion is crucial to facilitate the transfer hydrogenation. Various ketones including alkyl aryl ketones, ketoesters, and an aryl heteroaryl ketone were competent substrates. An attractive feature of this catalysis is efficient discrimination between the alkyl and aryl substituents of the ketones, promoting hydrogenation with the identical sense of enantioselection regardless of steric demand of the alkyl substituent and thus resulting in a rare case of highly enantioselective transfer hydrogenation of tert-alkyl aryl ketones. Quantum chemical calculations revealed that the sp(3)-C-H/pi interaction between an sp(3)-C-H bond of the prolinol-phosphine ligand and the aryl substituent of the ketone is crucial for the enantioselection in combination with O-H center dot center dot center dot O/sp(3)-C-H center dot center dot center dot O two-point hydrogen-bonding between the chiral ligand and carbonyl group.

Welcome to talk about 91-02-1, If you have any questions, you can contact Murayama, H; Heike, Y; Higashida, K; Shimizu, Y; Yodsin, N; Wongnongwa, Y; Jungsuttiwong, S; Mori, S; Sawamura, M or send Email.. HPLC of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem