Radical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide was written by Dix, Stefan;Golz, Paul;Schmid, Jonas R.;Riedel, Sebastian;Hopkinson, Matthew N.. And the article was included in Chemistry – A European Journal in 2021.Name: 6-Fluoronicotinonitrile This article mentions the following:
Herein, bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent, which easily accessible from inexpensive bulk chems. was introduced. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which was previously prepared via multi-step approaches. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Name: 6-Fluoronicotinonitrile).
6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 6-Fluoronicotinonitrile