On November 7, 1995, Dobrusin, Ellen M.; Showalter, Howard D. H.; Denny, William A.; Palmer, Brian D.; Rewcastle, Gordon W.; Tercel, Moana; Thompson, Andrew M. published a patent.Related Products of 156267-13-9 The title of the patent was Preparation of 2-indolyldisulfides and analogs as protein tyrosine kinase inhibitors and antitumor agents. And the patent contained the following:
Title compounds [I; R1 = H, halo, alkyl, alkoxy, etc.; R2 = (acyl)alkyl, acyl, CH:CHCO2H, etc.; R3 = H, alkyl, CH2Ph; R4 = SH, SnR, SeH, SenR, etc.; R = H, alkyl, (hetero)aryl, I in which R4 = bond, etc.; R4R5 = S, Se; R5R6 = bond; R6 = H; n = 1-3] were prepared 2Hus, 1-methyl-2-indolinone was treated with P2S5 and the product condensed with PhNCO to give, after oxidation, title compound II which had IC50 of 3-4μM against growth factor mediated mitogenesis in vitro. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Related Products of 156267-13-9
The Article related to indolyldisulfide preparation protein tyrosine kinase inhibitor, antitumor indolyldisulfide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 156267-13-9