Dogan, Sengul Dilem; Demirpolat, Eren; Yerer Aycan, Mukerrem Betul; Balci, Metin published an article on January 14 ,2015. The article was titled 《Synthesis of new 4-aza-indoles via acyl azides》, and you may find the article in Tetrahedron.COA of Formula: C9H12N2O2 The information in the text is summarized as follows:
The authors hereby report the preparation of new azaindole derivatives starting from 2-(2-ethoxy-2-oxoethyl)nicotinic acid. Conversion of a half ester into acyl azide followed by Curtius rearrangement gave the corresponding isocyanate. Trapping of the isocyanate with different nucleophiles produced urea and urethane derivatives Intramol. cyclization reactions gave the target compounds In addition to this study using Ethyl 2-(3-aminopyridin-2-yl)acetate, there are many other studies that have used Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4COA of Formula: C9H12N2O2) was used in this study.
Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.COA of Formula: C9H12N2O2