Decarboxylative Borylation and Cross-Coupling of (Hetero)aryl Acids Enabled by Copper Charge Transfer Catalysis was written by Dow, Nathan W.;Pedersen, P. Scott;Chen, Tiffany Q.;Blakemore, David C.;Dechert-Schmitt, Anne-Marie;Knauber, Thomas;MacMillan, David W. C.. And the article was included in Journal of the American Chemical Society in 2022.Recommanded Product: 2-Chloro-5-fluoropyridin-3-ol This article mentions the following:
Authors report a copper-catalyzed strategy for arylboronic ester synthesis that exploits photoinduced ligand-to-metal charge transfer (LMCT) to convert (hetero)aryl acids into aryl radicals amenable to ambient-temperature borylation. This near-UV process occurs under mild conditions, requires no prefunctionalization of the native acid, and operates broadly across diverse aryl, heteroaryl, and pharmaceutical substrates. They also report a one-pot procedure for decarboxylative cross-coupling that merges catalytic LMCT borylation and palladium-catalyzed Suzuki-Miyaura arylation, vinylation, or alkylation with organo bromides to access a range of value-added products. The utility of these protocols is highlighted through the development of a heteroselective double-decarboxylative C(sp2)-C(sp2) coupling sequence, pairing copper-catalyzed LMCT borylation and halogenation processes of two distinct acids (including pharmaceutical substrates) with subsequent Suzuki-Miyaura cross-coupling. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-fluoropyridin-3-ol (cas: 884494-35-3Recommanded Product: 2-Chloro-5-fluoropyridin-3-ol).
2-Chloro-5-fluoropyridin-3-ol (cas: 884494-35-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 2-Chloro-5-fluoropyridin-3-ol