Recently I am researching about SITU CLICK-CHEMISTRY; BENZOTRIAZOLE-ASSISTED SYNTHESIS; PLASMINOGEN-ACTIVATOR SYSTEM; IN-SITU; MULTICOMPONENT REACTIONS; COMBINATORIAL CHEMISTRY; GUIDED SYNTHESIS; PROTEASE; ACETYLCHOLINESTERASE; AMINOALKYLATION, Saw an article supported by the Research Foundation, Flanders (FWO)FWO [12O5417NLV]; FWOFWO [G0A 5516N513]; University Research Fund (BOF-KP). Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Gladysz, R; Vrijdag, J; Van Rompaey, D; Lambeir, AM; Augustyns, K; De Winter, H; Van der Veken, P. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Computed Properties of C6H5NO
Target-guided synthesis (TGS) has emerged as a promising strategy in drug discovery. Although reported examples of TGS generally involve two-component reactions, there is a strong case for developing target-guided versions of three-component reactions (3CRs) because of their potential to deliver highly diversified druglike molecules. To this end, the Groebke-Blackburn-Bienayme reaction was selected as a model 3CR. We recently reported a series of druglike urokinase inhibitors, and these serve as reference compounds in the present study. Due to the limited number of literature reports on target-guided 3CRs, multiple experimental parameters were optimized here. Most challenging was the formation of imine intermediates under near-physiological conditions. This aspect was addressed by exploring chemical imine stabilization strategies. Notably, imines are also crucial intermediates of other 3CRs. Such systematic studies are strongly required for further development of the TGS domain but are largely absent in the literature. Hence, this work is intended as a reference for future multicomponent-based TGS studies.
Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Gladysz, R; Vrijdag, J; Van Rompaey, D; Lambeir, AM; Augustyns, K; De Winter, H; Van der Veken, P or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem