Zhang, Jin; Zhang, Pei; Shao, Lei; Wang, Ruihong; Ma, Yangmin; Szostak, Michal published the article 《Mechanochemical Solvent-Free Suzuki-Miyaura Cross-Coupling of Amides via Highly Chemoselective N-C Cleavage》. Keywords: amide arylboronic acid palladium catalyst Suzuki Miyaura cross coupling; biaryl ketone chemoselective preparation; Amide bonds; Mechanochemistry; N−C cleavage; Solvent-free; Suzuki-Miyaura cross-coupling.They researched the compound: Palladium(II) acetate( cas:3375-31-3 ).Electric Literature of C4H6O4Pd. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3375-31-3) here.
The first mechanochem. strategy for highly chemoselective, solvent-free palladium-catalyzed cross-coupling of amides by N-C bond activation was reported. The method was conducted in the absence of external heating, for short reaction time and shows excellent chemoselectivity for σ N-C bond activation. The reaction showed excellent functional group tolerance and could be applied to late-stage functionalization of complex APIs and sequential orthogonal cross-couplings exploiting double solventless solid-state methods. The results extend mechanochem. reaction environments to advance the chem. repertoire of N-C bond interconversions to solid-state environmentally friendly mechanochem. methods.
This compound(Palladium(II) acetate)Electric Literature of C4H6O4Pd was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.