Name: 2,4-Dimethyl-1H-pyrrole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about A nitroolefin based thiol fluorescent probe: synthesis and application in bioimaging. Author is Guo, Zhenbo; Zheng, Xueyang; Li, Xueyan; Jia, Qingfei; Zhang, Pingzhu; Wei, Chao; Li, Xiaoliu.
Intracellular small-mol. thiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play pivotal roles in several physiol. and pathol. processes. A bodipy-nitroolefin-conjugated fluorescent probe based on photoinduced electron transfer (PET) mechanism was designed and successfully constructed. The probe selectively responds to biothiols by Michael addition reaction of the sulfhydryl group to the double bond activated by Nitroolefin moiety and gives an off-on fluorescent response. The fluorescence detection limit for GSH was calculated to be 11×10-9 mol/L. The results of fluorescence confocal imaging indicated that the probe has appreciable cell permeability and can serve as a fluorescent probe for detecting biothiols in living cells and zebrafish.
Different reactions of this compound(2,4-Dimethyl-1H-pyrrole)Name: 2,4-Dimethyl-1H-pyrrole require different conditions, so the reaction conditions are very important.