Halogen Bonding Molecular Capsules was written by Dumele, Oliver;Trapp, Nils;Diederich, Francois. And the article was included in Angewandte Chemie, International Edition in 2015.Electric Literature of C7H9NO This article mentions the following:
Mol. capsules based solely on the interaction of halogen bonding (XB) were presented along with their host-guest binding properties in solution The first example of a well-defined four-point XB supramol. system was realized by decorating resorcin[4]arene cavitands with polarized halogen atoms for dimerization with tetra(4-pyridyl)-substituted resorcin[4]arene cavitands. NMR binding data for the F, Cl, Br, and I cavitands as the XB donor showed association constants (Ka) of up to 5370 Μ-1(ΔG283 K=-4.85 kcal mol-1, for I), even in XB-competitive solvent, such as deuterated benzene/acetone/methanol (70:30:1) at 283 K, where comparable monodentate model systems show no association The XB capsular geometry was evidenced by two-dimensional HOESY NMR, and the thermodn. profile showed that capsule formation was enthalpically driven. Either 1,4-dioxane or 1,4-dithiane were encapsulated within each of the two sep. cavities within the XB capsule, with of up to Ka=9.0 108 Μ-2 (ΔG283 K=-11.6 kcal mol-1). In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Electric Literature of C7H9NO).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C7H9NO