Ebrahimi, Ali; Schwartzman, Julia; Cordero, Otto X. published the artcile< Multicellular behaviour enables cooperation in microbial cell aggregates>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is Vibrio multicellular behavior cell aggregation; alginate; microbial aggregate; self-organization; trait-based model.
Oligosaccharides produced from the extracellular hydrolysis of biol. materials can act as common goods that promote cooperative growth in microbial populations, whereby cell-cell aggregation increases both the per capita availability of resources and the per-cell growth rate. We built a computational model, which predicts cooperation is restricted in dense cell aggregates larger than 10μm because of the emergence of polymer and oligomer counter gradients. We compared these predictions to experiments performed with two well-studied alginate-degrading strains of Vibrio splendidus, which varied in their ability to secrete alginate lyase. We observed that both strains can form large aggregates (less than 50μm), overcoming diffusion limitation by rearranging their internal structure. The stronger enzyme producer grew non-cooperatively and formed aggregates with internal channels that allowed exchange between the bulk environment and the aggregate, whereas the weak enzyme producer showed strongly cooperative growth and formed dense aggregates in which cells near the core mixed by active swimming. Our simulations suggest that the mixing and channelling reduce diffusion limitation and allow cells to uniformly grow in aggregates. Together, these data demonstrate that bacterial behavior can help overcome competition imposed by resource gradients within cell aggregates. This article is part of a discussion meeting issue ‘Single cell ecol.’.
Philosophical Transactions of the Royal Society, B: Biological Sciences published new progress about Cell aggregation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.