Ehrhardt, Alexandre; Mandelli, Jessica Zolim Andreatto; Bergamo, Vanessa; Lopes, William; Donato, Ricardo Keitel; Zanette, Regis A.; Fuentefria, Alexandre Meneghello published the artcile< Glass ionomer cement modified by a imidazolium salt: adding antifungal properties to a biomaterial>, Reference of 123-03-5, the main research area is glass ionomer cement imidazolium antifungal property; Antibiofilm activity; Candida spp; Dental material.
We present the structural modification of a com. available glass ionomer cement by inserting the imidazolium salt 1-n-hexadecyl-3-methylimidazolium chloride (C16MImCl), composing a new biomaterial with antifungal biofilm activity. Test specimens were prepared using a com. glass ionomer cement to which 10 ppm of cetylpyridinium chloride (reference ionic antifungal agent) or C16MImCl were added. The feasibility and hypoallergenicity of the new biomaterial were assessed by microhardness plastic deformation and chorioallantoic membrane assays. Colony counting and SEM were used to evaluate the modified specimens’ antibiofilm activity against three multidrug-resistant Candida species. The modified glass ionomer cement presented a strong antibiofilm activity against Candida spp., without losing its original micromech. and hypoallergenic properties, rendering it a promising candidate for further application in dentistry.
Brazilian Journal of Microbiology published new progress about Antibiofilm agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.