Elvidge, J. A.; Zaidi, N. A. published the artcile< Heterocyclic syntheses with malonyl chloride. IX. 2-Substituted 4-chloro-6-pyrimidones from certain nitriles>, Application of C5HCl4N, the main research area is nitriles malonyl chloride; malonyl chloride nitriles; pyrimidines; pyridines.
Chloroacetonitrile with malonyl chloride yielded 2,3-dichloro-4,6-dihydroxypyridine (I) together with an unexpected product, 4-chloro-2-chloromethyl-6-pyrimidone (II). Further examples of this new synthesis of 2-substituted 4-chloro-6-pyrimidones were obtained with fluoro- and bromoacetonitrile, α-bromopropionitrile, and acetonitrile. Propio- and butyronitrile each gave a mixture of pyridine and pyrimidine product, while various other nitriles gave only the pyridine products. The expected fully substituted pyrimidone was obtained from fluoroacetonitrile and chloromalonyl chloride, and from dibromoacetonitrile with bromomalonyl chloride. Some novel halogen-transfer reactions were encountered in other cases.
Journal of the Chemical Society [Section] C: Organic published new progress about Nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Application of C5HCl4N.