Epsztajn, J.; Plotka, M. W.; Grabowska, A. published the artcile< Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metalation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids>, Reference of 53636-56-9, the main research area is picolinic acid halogenated preparation; isonicotinic acid halogenated preparation; halogenated picolinic isonicotinic acid preparation.
The synthesis of the halogenated picolin- and isonicotinanilides I (R = Cl, Br, iodo, X = N, Y = CH; X = CH, Y = N) (II) via metalation (n-BuLi) of the anilides I (R = H) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl3-CCl3, CH2Br-CH2Br, I2) followed by subsequent acidic hydrolysis of II, as a way of regiospecific transformation of picolinic and isonicotinic acids into their C3-halogenated derivatives, is described.
Synthetic Communications published new progress about Regiochemistry. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Reference of 53636-56-9.