Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors was written by Esposito, Anna;De Gregorio, Eliana;De Fenza, Maria;D’Alonzo, Daniele;Satawani, Anil;Guaragna, Annalisa. And the article was included in RSC Advances in 2019.Application In Synthesis of Pyridinehydrochloride This article mentions the following:
The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-neg. and -pos. bacteria. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of Pyridinehydrochloride