Choudhury, Shubhranshu Shekhar;Mahapatra, Shivam;Biswal, Himansu S. published 《Hydrogen bond mediated conversion of benzenenitriles and arylacetonitriles to amides: an “on/in-water” reaction strategy》. The research results were published in《Green Chemistry》 in 2022.Formula: C6H4N2 The article conveys some information:
Owing to the myriad of applications that amides have, hydration of nitriles has emerged as one of the most preferred atom-efficient synthesis methods. Being kinetically slow, this strategy requires some efficient catalysts. Herein, authors discovered choline hydroxide as an environmentally benign, metal-free and inexpensive catalyst for the hydration of aromatic and heteroaromatic nitriles on/in water with excellent yields. All the reactions proceeded under mild/moderate conditions, facilitated by the hydrogen bonds between the catalyst and the reactant or intermediate. D. functional theory (DFT) studies were used to propose the plausible reaction mechanism, which was further corroborated with kinetics measurements using quant. 19F NMR spectroscopy, thereby revealing the presence of H-bond mediated catalysis which brought down the activation energy barrier even lower than those in previous reports on using H2SO4 or Ru(OH)x/Al2O3 as catalysts. This work offers an “on/in-water” reaction strategy for the efficient hydration of nitriles and will pave the path towards novel routes for the com. synthesis of amides. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.
3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Formula: C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.