Electric Literature of 1015610-31-7 ,Some common heterocyclic compound, 1015610-31-7, molecular formula is C7H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a nitrogen atmosphere, 9H-carbazole (5 g, 29.9 mmol) was dissolved in toluene (70 mL)4-chloro-5-iodo-1H-pyrrolo [2,3-b] pyridine (8.33 g, 29.9 mmol, product number: ADE000983)Tris (diphenylideneacetone) dipalladium (0) (0.27 g, 0.30 mmol),Tris-tert-butylphosphine (0.30 g, 1.50 mmol) and sodium tert-butoxide (3.45 g, 35.9 mmol) were successively added thereto and refluxed by heating at 100 C for 13 hours.After the completion of the reaction, water was added to the reaction solution, and the mixture was extracted with dichloromethane (DCM), and the water was removed with anhydrous MgSO 4. The extract was filtered and concentrated under reduced pressure.The thus-obtained residue was purified by flash column chromatography to obtain Compound I-4 (9.03 g, 95%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1015610-31-7, 4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Cheil Industries Co.,Ltd; Lee, Han Ir; Yoo, Eun Sun; Kang, Dong Min; Sin, Ji Hun; Yoo, Dong Kyu; Lee, Sang Sin; Jang, Yoo Na; Jung, Soo Young; Han, Su Jin; Hong, Jin Suk; (46 pag.)KR2015/24669; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem