Adding a certain compound to certain chemical reactions, such as: 105170-27-2, 2-Bromo-5-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 105170-27-2, blongs to pyridine-derivatives compound. category: pyridine-derivatives
5-methyl-4-{[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamino]-methyl-furan-2-carboxylic acid methyl ester (164) (130mg, 0.525mmoles) was added to a degassed mixture of 2-bromo-5-methoxy-pyridine (99mg, 0.350mmoles), bis-(dibenzylidene-acetone)-palladium(0) (6mg) and triphenylphosphine (11mg) in toluene/dimethylformamide 1 : 1 v/v (5ml) under an argon atmosphere. Aqueous potassium carbonate (0.23ml of a 3M solution) was added and the mixture was heated at 100C for 16 hours. The reaction mixture was concentrated and the residue was purified by HPLC to afford compound 165 (38mg). LC/MS System A; Rt = 2.55mins, m/z (ES+) = 353 (M+H for C20H20N2O4)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,105170-27-2, its application will become more common.
Reference:
Patent; PHARMAGENE LABORATORIES LIMITED; WO2004/67524; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem