Reference of 109345-94-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109345-94-0, name is 5-Methoxypyridin-3-ol, molecular formula is C6H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 40A 5-Methoxy-2-nitropyridin-3-ol (0698) (0699) 1) Under argon, 1.46 g (4.8 mmol) of tetra-n-butylammonium nitrate were initially charged in 10 ml of dichloromethane, 0.68 ml (4.8 mmol) of trifluoroacetic anhydride was added slowly at 0 C. and the mixture was stirred at 0 C. for 10 min (0700) 2) Under argon, 500 mg (4 mmol) of 5-methoxypyridin-3-ol were dissolved in a separate reaction flask in 10 ml of dichloromethane, and the solution from step 1) was added dropwise at -30 C. The reaction mixture was stirred in the thawing ice bath (not exceeding 0 C.) for 4 h. Kieselguhr was added and the reaction solution was concentrated at low temperature and purified by silica gel chromatography (mobile phase: cyclohexane/ethyl acetate: 9/1). This gave 637 mg of the target compound (94% of theory, purity 100%). (0701) LC-MS (Method 1): Rt=0.58 min (0702) MS (ESpos): m/z=171 (M+H)+ (0703) 1H-NMR (400 MHz, DMSO-d6): delta=3.90 (s, 3H), 7.11 (d, 1H), 7.78 (d, 1H), 11.35 (br. 1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109345-94-0, 5-Methoxypyridin-3-ol.
Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; VALOT, Gaelle; LINDNER, Niels; FOLLMANN, Markus; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, Tobias; REDLICH, Gorden; DIETZ, Lisa; Ll, Volkhart Min-Jian; (94 pag.)US2017/57954; (2017); A1;,
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