The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112110-07-3, name is 5-(Trifluoromethyl)pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 5-(Trifluoromethyl)pyridin-3-amine
5-(Trifluoromethyl)pyridin-3 -amine (977 mg, 6.03 mmol, Anichem, P20551 , North Brunswick, NJ) was treated with THF (40 mL) and LiHMDS (1.0 M in THF, 13.26 mL, 13.26 mmol) slowly dropwise at RT and stirred at this temperature for 20 min. The solution was then cooled in an ice bath and di-tert-butyl dicarbonate (1.38 g, 6.33 mmol) was added and the solution stirred warming to RT overnight. LC-MS indicated partial conversion to bis(Boc) material (M+l =363.2). The reaction mixture was treated with additional di-tert-butyl dicarbonate (1.38 g, 6.33 mmol) and of 1M LiHMDS and stirred overnight (16 h). The reaction mixture was concentrated and the crude material was treated with 0.2M HC1 (aq., 30 mL) and extracted with EtOAc (100 mL). The organic layer was washed with a saturated solution of NaHCC>3 (aq.) and brine and dried over MgS04, filtered and concentrated. The resulting crude product was purified by silica gel chromatography (20-50% EtOAc in hexanes) to afford bis(teri-butyl (5- (trifluoromethyl)pyridin-3-yl)carbamate) (729 mg, 33 % yield) as a yellow crystalline solid. MS (ESI, pos. ion) m/z: 363.0 (M+l). .H NMR (400 MHz, CDCl3) delta ppm 8.80 (1 H, s), 8.58 – 8.64 (1 H, m), 7.75 (1 H, s), 1.44 (18 H, s). 19F NMR (377 MHz, CDCl3) delta ppm -62.36 (3 F, s).
With the rapid development of chemical substances, we look forward to future research findings about 112110-07-3.
Reference:
Patent; AMGEN INC.; D’AMICO, Derin C.; HERBERICH, Bradley J.; JACKSON, Claire L.M.; PETTUS, Liping H.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan; WO2012/148775; (2012); A1;,
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